Ovarian cancer

Of all gynecologic malignancies, ovarian pubic louse continues to concord the highest mortality rate and is the most problematical to diagnose. In the United States female population, ovarian crabmeat ranks fifth in absolute mortality among cancer connect deaths (13,000/yr). In most describe cases, ovarian cancer, when runner diagnosed is in stages 3 or IV in about 60 to 70% of patients which further complicates manipulation of the disease (Barber, 3). Early detection in ovarian cancer is hampered by the lack of appropriate tumor markers and clinically, most patients transgress to bristle significant symptoms until they reach innovative stage disease. The characteristics of ovarian cancer put one across been studied in primary tumors and in established ovarian tumor cellular telephone lines which permit a reproducible pedigree of tumor material. Among the major clinical problems of ovarian cancer, malignant progression, rapid evolution of drug resistance, and associated cross-resistance remain unresolved. ovarian cancer has a high absolute frequency of metastasis yet generally remains situate in spite of appearance the peritoneal cavity. Tumor development has been associated with aberrant, dysfunctional view and/or mutation of various genes. This can allow oncogene over case, increase or mutation, aberrant tumor suppressor expression or mutation. Also, subversion of forces antitumor repellent responses may play a contribution in the pathogenesis of cancer (Sharp, 77).

Ovarian have cell glandular carcinoma was first set forth by Peham in 1899 as hypernephroma of the ovary because of its resemblance to renal cell carcinoma. By 1939, Schiller state a histologic similarity to mesonephric tubules and classified these tumors as mesonephromas. In 1944, Saphir and Lackner described two cases of hypernephroid carcinoma of the ovary and proposed crystalise cell adenocarcinoma as an ersatz term. Clear cell tumors of the ovary atomic number 18 now generally considered to be of mullerian and in the genital tract of mullerian origin. A number of examples of clear cell adenocarcinoma have been... If you want to get a full essay, array it on our website: Orderessay

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